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What would sanitiser fail to do that detergent and warm water would do in cleaning glasses frame that isn’t ‘visibly soiled’?

For an arbitrary glasses frame, specifically the earsocks, can regular alcohol/sanitiser replace detergent and warm water? Apparently some brands of glasses frames recommend really detergent and warm water. I mean, with alcohol and sanitiser, am I perhaps killing only 99% of the germs instead of 99.9% of the germs? (If we wanted planes to be safe "with statistical significance" that is 99% confidence level we’d have between 400 and 2500 crashes a day.)

I couldn’t find any videos for this on youtube. Most of what youtube gives is cleaning ears or cleaning the lenses.

Edited to add: I got the following with my new glasses.

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Kind of a hassle to do the recommendation especially that I’ve never cleaned glasses frames in my 13 years of wearing of glasses, except when they were, to borrow a term from WHO, ‘visibly soiled‘:

Clean your hands by rubbing them
with an alcohol-based formulation,
as the preferred mean for routine
hygienic hand antisepsis if hands
are not visibly soiled. It is faster,
more effective, and better tolerated
by your hands than washing with
soap and water.

• Wash your hands with soap and water
when hands are visibly dirty or visibly
soiled with blood or other body fluids
or after using the toilet.

Alcohol is a substitute for soap and water for hands that are not ‘visibly soiled’. Is there perhaps some kind of substitute for glasses frame?

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