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“challenges associated with drug design” What does it mean?

I was reading the news here: https://www.drugtargetreview.com/article/60516/developing-immunotherapies-for-hard-to-treat-cancers/ And then I saw “challenges associated with drug design” in this sentence: He continued that the targeted and versatile action of the triangle offence and its ability to reduce immune suppression by the tumour microenvironment means it overcomes many of the downfalls of other treatments and challenges associated […]