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How is Facilitated Diffusion saturable but simple diffusion not?

In some cases it is pretty clear why Simple diffusion is not saturable but in cases like the movement of molecules through ligand gated channels I’m finding difficult to see how they’re not saturable. My book says: “What is it that limits the rate of facilitated diffusion? A probable answer is the mechanism illustrated in […]

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Can a gene span several kb?

Can you have exons and introns of the same gene separated by hundred of kb in a genome? If so, how is the full ARNm assembled in such distance? I’m working on plant mitochondria and I’ve seen an annoted gene that is cut between very distinct part of the genome.

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How does the immune system distinguish between a TH1 and a TH2 response?

Hello and thanks for taking the time to read my post. I know that naive T-Cells (T0) can be induced to become mature T-Helper cells (TH1 or TH2) by induction with either IL2 or IL4. IL2+ TH0 -> TH1 Humoral (antibody-mediated) IL4+ TH0 -> TH2 Cell Mediated response But what I would like to know […]

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Can methanol be used to dissolve lipids and protein structure (disinfect Corona virus)?

According to my quick research, disinfecting an enveloped virus can be achieved by simply taking its lipid spikes and protein envelope apart. Therefore “anything that can dissolve fat and protein structure”[¹] can be used to disintegrate (disinfect) the virus permanently, such as soap + water, alcohol, heat, UV, bleach, etc. [¹]: This is my interpretation, […]

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Covid-19: Is it possible to get to r0

I’m trying to wrap my head around some of the information I’m reading about how to fight Covid-19 and conflicting opinions about how much “social distancing” is required to avert a disaster, or whether social distancing works at all. (I am a data scientist, not a biologist or medical professional) First I want to check […]

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If every person between 15-60 had an immune system equal to the healthiest people, would this affect the spread of coronavirus?

Has anyone calculated the speed or breadth of the spread of something like coronavirus (or any cold, flu, airborne pathogen) based on how well the population can master the virus with their immune system? Just as a simple example, let’s say you shortened the window of contagiousness by 2 days. Would that have a significant […]

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What gene targets associated with the new coronavirus (SARS-CoV-2) have been identified so far?

Scientists have demonstrated that the new virus “enters human cells through an interaction with angiotensin-converting enzyme 2” hence the idea to target the gene that modulates this enzyme see here. Wondering if there are other studies that have identified different genes that can be modulated to fight the infection and if we can make a […]

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Are there any instances of coronaviruses being directly transmitted from bats to humans?

Many human coronaviruses have ancestral host origins in species of bat. However, all instances I am aware of identified other animals as intermediary vectors: SARS-CoV: Human < Himalayan Palm Civet/Raccoon < Bat MERS-CoV: Human < Dromedary Camel < Bat HCoV-229E: Human < Alpaca < Bat Are there any known cases of direct bat to human […]

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Wouldn’t it be smarter to fight the coronavirus this way?

It is commonly said that most people, especially the healthiest would only develop mild syndromes. Therefore, shouldn’t we, instead of confining all the population as a whole proceed as follows : A/ isolate the most fragile people (older people or those with known health issues) in their home or in some other safe places. B/ […]

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How to filter out the antibody light chains into kappa and lambda types on the PDB website?

The antibody light chains can either be kappa or lambda types. I am searching homologous sequences on the RCSB PDB website. Is there a way to filter out these two types?